AB0428 ULTRASOUND ASSESSED NAIL BED THICKNESS AS AN EARLY SCREENING MARKER FOR INTERSTITIAL LUNG DISEASE IN SCLERODERMA

Background: Interstitial lung disease (ILD) is the most frequent pulmonary manifestation of scleroderma and seen in 80% patients with diffuse 20% limited forms scleroderma. 1 Even early stages varying degrees severity, it does not correlate clinical manifestations. 2 Hence, difficult to select for ILD screening based on symptoms. Digital clubbing a common feature has been associated poor prognosis. 3 Objectives: To assess ultrasound measured nail bed thickness (NBT) cases as marker detect its inter-digital variation. Methods: A prospective observational study involving 15 each ILD, without controls visiting our clinic from August 2020 December were included. The presence was confirmed by HRCT thorax. Patients history smoking, alcohol intake or pre-existing cardio-respiratory illnesses excluded. Ultrasound assessed NBT calculated using Philips affiniti 70 eL18-4 probe. total 436 beds recorded (142 144 150 control group). 14 nails excluded due trauma. Statistical analysis done ANOVA test. Results considered significant at p value < 0.05. Results: On comparing among groups, difference statistically all three except left st finger (Table 1). NBT’s group did show between two groups. Whereas, when compared group, statistical significance found (p<0.001) fingers both hands, 1st 2nd right hand respectively. individual groups (p =0.002), 4th (p=0.009) 5th (p=<0.001) noted. In hand, same had (p<0.001). Conclusion: are predisposed an increase NBT, which can be detected ultrasound. Thus, increased may have role detection patients. Further studies large patient data should look utilized scleroderma, widely available inexpensive tool. References: [1]Boin F, Wigley FM. Clinical Features Treatment Scleroderma. In:Firestein G, Budd R, Sherine E, et al, eds. Kelley’s Textbook Rheumatology. Philadelphia, PA: Elsevier; 2013:1366–1403. [2]Hassan RI, al. Lung method interstitial systemic sclerosis. JCR: Journal 2019;25(7):304-7. [3]T.E. King Jr., J.A. Tooze, M.I. Schwarz, K.R. Brown, R.M. CherniackPredicting survival idiopathic fibrosis: scoring system model Am. J. Respir. Crit. Care Med., 164 (7) (2001), 1171-81. Table 1. Nail Finger Scleroderma n=15 Control p-value Mean SD Right 1.86 0.239 1.71 0.081 1.69 0.107 0.021 nd 1.73 0.303 1.50 0.079 1.61 0.108 0.003 rd 1.89 0.200 1.75 0.091 0.131 <0.001 4 th 1.80 0.263 1.39 0.147 1.35 0.078 5 0.119 1.24 0.095 1.29 0.069 Left 1.98 0.442 1.72 0.084 1.68 0.050 1.82 0.123 1.57 0.125 0.092 2.05 0.309 1.76 1.42 0.109 1.92 0.246 1.36 0.130 1.81 0.158 1.15 0.368 1.23 0.103 Figure measurement Disclosure Interests: None declared